Endocrine Abstracts

Recent health reports state that the population of western countries is consuming excessive amounts of n-6 polyunsaturated fatty acids (PUFAs) in the diet. Dietary n-6 PUFAs are precursors for prostaglandin (PG) synthesis, which play important roles in parturition. Increased dietary n-6 PUFA could thus alter PG production. This study determined the effect of a high n-6 PUFA diet on PG production and the timing of the onset of labour. Pregnant Welsh Mountain ewes were fed an is...

2-Methoxyoestradiol (2-MeOE2) is a human endogenous metabolite of oestradiol which is known to inhibit the proliferation of breast cancer cells. Sulphamoylation of 2-MeOE2 greatly enhances its ability to inhibit breast cancer cell proliferation and induce apoptosis. To establish whether 2-MeOE2 and its mono- and bis-sulphamoylated derivatives would also be an effective treatment for other endocrine cancers, we have investigated their effects, and those of 2-ethyloestradiol (2-...